Preparation and Evaluation of Acacia nilotica Gum Microsphere Using Various Cross-Linking Agents

Preparation and Evaluation of Acacia nilotica Gum Microsphere Using Various Cross-Linking Agents

Registration ID: IJNRD_182160

Published ID: IJNRD2207160

DOI: Click Here to Get

vandana Chaudhary , Dr.Punit Parejiya

Acacia nilotica, Natural Polymer, Microsphere, Famotidine, Ionotropic Gelation.

Objective:The aim of present study was to formulate natural polymer Acacia nilotica gum based Famotidine microsphere which is improve its therapeutic efficacy, patient compliance and reduce the dosing frequency and adverse effects. Methods: Different batches of microspheres were prepared by ionotropic gelation technique. The physicochemical parameters like drug content, particle size measurement, swelling index and percentage yield as well as in vitro drug release were determined using USP Type 1 apparatus. SEM study was done for the optimized microspheres. Result: Eighteen batches of microspheres were prepared by natural polymer Acacia nilotica gum and drug loaded Famotidine. All prepared batches of microspheres evaluated different parameters like particle size is having 846.21 to 989.04µm, F5 shows highest particle size. Micromeritics properties that are bulk density tapped density, carr, s index, hausner ratio, angle of repose and found excellent flow and packaging properties. Percentage yield of microsphere has well. Formulation F1 shows maximum % yield of microspheres. Drug content % was found 98% F1 batch. Swelling % formulation F5 shows maximum swelling property. Drug and polymer is compatible to each other. Percent release of drug is 98% in 8 hours. Conclusion: This study final from the obtained results, it could be concluded that Famotidine natural polymer microspheres can be formulated as controlled and sustained release of drug for several hours.

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"Preparation and Evaluation of Acacia nilotica Gum Microsphere Using Various Cross-Linking Agents", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 7, page no.1420-1431, July-2022, Available :https://ijnrd.org/papers/IJNRD2207160.pdf

Volume 7 Issue 7, July-2022

Pages : 1420-1431

Paper Reg. ID: IJNRD_182160

Published Paper Id: IJNRD2207160

Downloads: 000121115

Research Area: Pharmacy

Country: ahmedabad, gujrat, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2207160.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2207160

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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