FORMULATION AND EVALUATION OF POLYMERIC MICROSPHERES OF GLIPIZIDE USING BOX BEHNKEN DESIGN

FORMULATION AND EVALUATION OF POLYMERIC MICROSPHERES OF GLIPIZIDE USING BOX BEHNKEN DESIGN

Registration ID: IJNRD_182060

Published ID: IJNRD2207070

DOI: Click Here to Get

Neelam Somani , Meenakshi Bharkatiya

Key words: - Glipizide, Korsmeyer Peppas Model, Scanning Electron Microscopy, Fourier Transform Infra-Red, Higuchi model, Regression, Fickian diffusion, single emulsion cross-linking technique.

Glipizide is a hypoglycemic agent to treat Diabetes Mellitus type II. In the present investigation, Glipizide loaded polymeric microspheres has been formulated by single emulsion technique. A, three level Box- Behnken design was applied to investigate the different components of formulation and process variables on the formulation response using the numeric approach through the design expert version 7.0 software. All the formulations (F1 to F17) were characterized for the particle size, drug entrapment efficiency and flow properties. F13 was obtained as optimized formulation with minimum particle size (µm), maximum drug entrapment efficiency % and good flow properties. Further the F13 formulation was characterized for In-vitro release, Scanning Electron Microscopy (SEM), Fourier Transform Infra- Red Spectroscopy (FTIR) study and stability testing. The graphs of Zero-order, First-order, Higuchi model and Korsmeyer Peppas model were plotted. The polymeric microspheres provide a sustained release of the Glipizide for more than 12 hours, following zero order release and Korsmeyer Peppas model with non- Fickian diffusion.

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"FORMULATION AND EVALUATION OF POLYMERIC MICROSPHERES OF GLIPIZIDE USING BOX BEHNKEN DESIGN", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 7, page no.548-574, July-2022, Available :https://ijnrd.org/papers/IJNRD2207070.pdf

Volume 7 Issue 7, July-2022

Pages : 548-574

Paper Reg. ID: IJNRD_182060

Published Paper Id: IJNRD2207070

Downloads: 000121112

Research Area: Pharmacy

Country: chittorgarh , rajasthan , india

Published Paper PDF: https://ijnrd.org/papers/IJNRD2207070.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2207070

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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