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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Impact Factor : 8.76

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Paper Title: FORMULATION AND EVALUATION OF POLYMERIC MICROSPHERES OF GLIPIZIDE USING BOX BEHNKEN DESIGN
Authors Name: Neelam Somani , Meenakshi Bharkatiya
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IJNRD_182060
Published Paper Id: IJNRD2207070
Published In: Volume 7 Issue 7, July-2022
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Abstract: Glipizide is a hypoglycemic agent to treat Diabetes Mellitus type II. In the present investigation, Glipizide loaded polymeric microspheres has been formulated by single emulsion technique. A, three level Box- Behnken design was applied to investigate the different components of formulation and process variables on the formulation response using the numeric approach through the design expert version 7.0 software. All the formulations (F1 to F17) were characterized for the particle size, drug entrapment efficiency and flow properties. F13 was obtained as optimized formulation with minimum particle size (µm), maximum drug entrapment efficiency % and good flow properties. Further the F13 formulation was characterized for In-vitro release, Scanning Electron Microscopy (SEM), Fourier Transform Infra- Red Spectroscopy (FTIR) study and stability testing. The graphs of Zero-order, First-order, Higuchi model and Korsmeyer Peppas model were plotted. The polymeric microspheres provide a sustained release of the Glipizide for more than 12 hours, following zero order release and Korsmeyer Peppas model with non- Fickian diffusion.
Keywords: Key words: - Glipizide, Korsmeyer Peppas Model, Scanning Electron Microscopy, Fourier Transform Infra-Red, Higuchi model, Regression, Fickian diffusion, single emulsion cross-linking technique.
Cite Article: "FORMULATION AND EVALUATION OF POLYMERIC MICROSPHERES OF GLIPIZIDE USING BOX BEHNKEN DESIGN", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 7, page no.548-574, July-2022, Available :http://www.ijnrd.org/papers/IJNRD2207070.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2207070
Registration ID: 182060
Published In: Volume 7 Issue 7, July-2022
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Page No: 548-574
Country: chittorgarh , rajasthan , india
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2207070
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2207070
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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