Dapagliflozin: mechanism and safety in heart failure patients: A review

Dapagliflozin: mechanism and safety in heart failure patients: A review

Registration ID: IJNRD_182064

Published ID: IJNRD2207060

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Lateef Ahmad Dar , Aasim Yousoof , Dr. Shah Aiman , Dr. H.C Patil

- Dapagliflozin, Heart Failure, SGLT2 Inhibitors, Diabetes Mellitus

Dapagliflozin, a specific inhibitor of sodium-glucose co transporter 2 (SGLT2), prevents the kidney's proximal tubule from reabsorbing glucose and increases glucosuria. Dapagliflozin lowers renal glucose reabsorption by blocking the transporter protein SGLT2 in the kidneys, which causes urine glucose excretion and a drop in blood glucose levels. Dapagliflozin's effectiveness is independent of insulin secretion and action, in contrast to oral antidiabetic medications from numerous other groups. Inhibiting sodium-glucose cotransporter 2 (SGLT2) has recently become a key treatment approach for lowering cardiovascular risk in Type 2 DM. The probability of heart failure (HF) hospitalization has been found to be decreased by sodium-glucose co-transporter 2 (SGLT2) inhibitors in extensive clinical trials in individuals with type 2 diabetes who are at high cardiovascular risk. This favorable outcome was seen quickly after randomization, pointing to a mechanism or mechanisms of action distinct from those often taken into account with traditional glucose-lowering treatments

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" Dapagliflozin: mechanism and safety in heart failure patients: A review", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 7, page no.480-485, July-2022, Available :https://ijnrd.org/papers/IJNRD2207060.pdf

Volume 7 Issue 7, July-2022

Pages : 480-485

Paper Reg. ID: IJNRD_182064

Published Paper Id: IJNRD2207060

Downloads: 000121175

Research Area: Medical Science

Country: Bathinda, Punjab, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2207060.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2207060

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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