PREPARATION AND EVALUATION OF TRANSDERMALDRUG DELIVERY SYSTEM CONTAINING AN HYPERTENSIVE DRUG

PREPARATION AND EVALUATION OF TRANSDERMALDRUG DELIVERY SYSTEM CONTAINING AN HYPERTENSIVE DRUG

Registration ID: IJNRD_181950

Published ID: IJNRD2207018

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Mr. Pradeep bansal , Dr. Akhilesh Kumar singhai , Mr. Mahadev kanere

Metoprolol Tartrate, Sodium alginate, Xanthan gum, Transdermal patch, Transdermal film.

The aim of the present study was to prepare and evaluate transdermal patches of Metoprolol Tartrate using sodium alginate and xanthan gum as biopolymers to minimize adverse effects associated with oral administration. Transdermal films of Metoprolol Tartrate with sodium alginate / xanthan gum by varying the blend ratios were prepared by solvent casting method. FTIR and DSC were studied to assess any interaction between the drug and the polymers. Drug loaded films were evaluated for physicochemical characteristics such as physical appearance, thickness, weight uniformity, folding endurance, % moisture absorption studies, , drug content uniformity, tensile strength, and in vitro diffusion was determined by Franz diffusion cell. The patches were tested for their potential to cause skin irritation in rats. Thin, flexible, smooth and transparent films of Metoprolol Tartrate was obtained with sodium alginate/xanthan gum blends. The FT-IR and DSC studies confirmed no interaction between the drug and polymers. Thickness, Tensile strength, folding endurance and % elongation were found to be uniform and reproducible.

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"PREPARATION AND EVALUATION OF TRANSDERMALDRUG DELIVERY SYSTEM CONTAINING AN HYPERTENSIVE DRUG", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 7, page no.138-154, July-2022, Available :https://ijnrd.org/papers/IJNRD2207018.pdf

Volume 7 Issue 7, July-2022

Pages : 138-154

Paper Reg. ID: IJNRD_181950

Published Paper Id: IJNRD2207018

Downloads: 000121122

Research Area: Engineering

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Published Paper PDF: https://ijnrd.org/papers/IJNRD2207018.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2207018

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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