Paper Title

FORMULATION, EVALUATION AND ANTIMICROBIAL ACTIVITY OF EVOLVULUS ALSINOIDES CREAM

Article Identifiers

Registration ID: IJNRD_181684

Published ID: IJNRD2206019

DOI: Click Here to Get

Authors

Athulya , Ashna Aji Haneef , Ashly S Abraham , Anjana S , Abini Daniel M, Ansa Mathew

Keywords

Evolvulus alsinoides (EA); Cream; Fusion method; Brookfield viscometer; Antimicrobial activity; Lawn culture; Agar diffusion method; Muller Hinton Agar (MHA); Staphylococcus aureus; Escherichia coli.

Abstract

Evolvulus alsinoides, commonly known as dwarf morning-glory and slender dwarf morning- glory, is flowering plant from the family Convolvulaceae. Traditionally this plant is used as blood purifier, brain tonic, an antimicrobial agent and for memory loss. This work is done for determining whether the cream prepared by the aqueous extract of Evolvulus alsinoides has antimicrobial activity. The dried plant leaves are extracted using water as the solvent. The extractive value is calculated and was found to be 12.5%𝑤⁄𝑤. The phytochemical screening of the extract was performed and it contains slight amount of glycosides, carbohydrates, proteins, alkaloids and tannins. Then using that aqueous extract, a cream was formulated and its evaluation was carried out. From the evaluation the cream was found to be light brown in color with a characteristic odour and have smooth texture. pH and viscosity of the cream are 5.58 and 13254mpas respectively. Cream was homogeneous by its visual appearance with a smooth and good consistency. On application, the cream was non-slippery, smooth and easily removable , also does not show any irritation on skin. After that the antimicrobial activity of the cream was tested using agar well diffusion method. Gentamicin was used as the standard reference drug. The antimicrobial sensitivity was determined using zone of inhibition. In our study, the cream containing aqueous extract displayed antimicrobial activity against Staphylococcus aureus and Escherichia coli. The cream was found to be more active against gram-negative (Escherichia coli) bacteria. The identified phytochemical compounds viz., glycosides, tannins and alkaloids may be responsible for the antimicrobial activity of Evolvulus alsinoides.

How To Cite (APA)

Athulya, Ashna Aji Haneef, Ashly S Abraham, Anjana S, & Abini Daniel M, Ansa Mathew (June-2022). FORMULATION, EVALUATION AND ANTIMICROBIAL ACTIVITY OF EVOLVULUS ALSINOIDES CREAM . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(6), 178-191. https://ijnrd.org/papers/IJNRD2206019.pdf

Issue

Volume 7 Issue 6, June-2022

Pages : 178-191

Other Publication Details

Paper Reg. ID: IJNRD_181684

Published Paper Id: IJNRD2206019

Downloads: 000121985

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2206019.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2206019

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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