“ ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CASSIA ABSUS AND ITS PHYTOCHEMICAL EVALUATION”

Registration ID: IJNRD_181237

Published ID: IJNRD2205048

DOI: Click Here to Get

Monika , Dr. Sambath kumar.R , Venkateswaran. V , Dr. Shanmughasundaram. R , Kanagasabai. R

Cassia absus , Anti-inflammatory, Carageenan induced paw edema.

The aim of present study was to investigate anti-inflammatory activities of its leaves extracts. Anti-inflammatory activities of Ethanolic extracts were evaluated by carageenan induced paw edema. Wister albino rat was used as a model for screening of anti-inflammatory activity. Group I served as disease control and Group II received Indomethacin (10mg/kg/i.p). Group III and IV of experimental animals received low dose (200mg), high dose (400mg) of ethanolic extract of Cassia absus linn. The paw volume was measured for Control, standard and low and high dose of test drug at one hour interval for six hours. From the statistical analysis it was concluded that the ‘Carrageenan induced’ Group I shows the inflammatory action and elevated level of Paw Volume is observed. But the III and IV group deals with the anti-inflammatory activity of the ethanolic extract of leaves of Cassia absus Linn. which gives low Paw Volume at the end of 6th h compared to standard drug. The anti-inflammatory activity is more effective in Group IV Carrageenan induction with oral administration of ethanolic extract of leaves of Cassia absus Linn. of 400 mg/kg/p.o compared to Group III in which Carrageenan given after the oral administration of ethanolic extract of leaves of Cassia absus Linn. of 200 mg/kg/i.p. Significant inhibition of paw edema was observed with both doses tested till the sixth hour. However, maximum inhibition of paw edema was found to be in Group IV 88.01 %. Since carrageenan-induced inflammation model is a significant predictive test for anti-inflammatory agents acting by the mediators of acute inflammation the results of this study are an indication that Cassia absus Linn. can be effective in acute inflammatory disorders.In this study, maximum inhibition of paw edema was found to be in Group IV pretreated with the ethanolic extract of leaves of Cassia absus Linn. (400 mg/kg).

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Monika, Dr. Sambath kumar.R, Venkateswaran. V, Dr. Shanmughasundaram. R, & Kanagasabai. R (May-2022). “ ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CASSIA ABSUS AND ITS PHYTOCHEMICAL EVALUATION”. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(5), 451-460. https://ijnrd.org/papers/IJNRD2205048.pdf

Volume 7 Issue 5, May-2022

Pages : 451-460

Paper Reg. ID: IJNRD_181237

Published Paper Id: IJNRD2205048

Downloads: 000121993

Research Area: Pharmacy

Country: Pudukottai, Tamilnadu, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2205048.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2205048

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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