Paper Title
Bone Cancer Pain, Therapeutic Opportunities, Causes and Consequences
Article Identifiers
Authors
Rohit Pralhadrao Kale , Arun Balaji Sontakke , Sanket Ankushrao Jadhav , Abhishek Changdeo Suryawanshi
Keywords
cancer, Bone growth, Pain, Sensations, Osteoclast, Experimental model
Abstract
The common type of cancers which are commonly found in the human beings include cancers of breast, prostate gland, lung which involves the metastasis to bones which lead to severe life altering pain. The progression of cancer drives the pain stimulus as well. After the metastasis of cells to bone, both cancer cells and their associated stromal cells generate the pain by releasing chemical messengers like endothelins, bradykinin, proteases, prostaglandins, and tyrosine kinase activators. These chemicals are released from the cancerous cells lead to introduce a sensitization and the activation of nerve fibers cause the bone pain. Along with bone pain these chemicals also can stimulate remarkable increase in the number activity of osteoclast and bone size which ultimately results into fracture of the bone that bears tumor. The growth in tumor part also may lead to neuropathic pain by causing damage to nerve fibre as well as inducing an active and highly pathological sprouting of both sensory and sympathetic nerve fibres that innervate the bone. The anatomical organization of the sympathetic nerve fibre and sensory nerve fibre are in combination with the cellular and neurochemical organization that occurs in CNS and appears to contribute in bone pain.
Downloads
How To Cite (APA)
Rohit Pralhadrao Kale, Arun Balaji Sontakke, Sanket Ankushrao Jadhav, & Abhishek Changdeo Suryawanshi (May-2022). Bone Cancer Pain, Therapeutic Opportunities, Causes and Consequences. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(5), 159-164. https://ijnrd.org/papers/IJNRD2205017.pdf
Issue
Volume 7 Issue 5, May-2022
Pages : 159-164
Other Publication Details
Paper Reg. ID: IJNRD_181255
Published Paper Id: IJNRD2205017
Downloads: 000121986
Research Area: Medical Science
Country: BEED, MAHARASHTRA, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2205017.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2205017
About Publisher
Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG
Licence
This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
Publication Timeline
Article Preview: View Full Paper
Call For Paper
IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.
The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.
Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.
How to submit the paper?
By Our website
Click Here to Submit Paper Online
Important Dates for Current issue
Paper Submission Open For: October 2025
Current Issue: Volume 10 | Issue 10 | October 2025
Impact Factor: 8.76
Last Date for Paper Submission: Till 31-Oct-2025
Notification of Review Result: Within 1-2 Days after Submitting paper.
Publication of Paper: Within 01-02 Days after Submititng documents.
Frequency: Monthly (12 issue Annually).
Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.
Subject Category: Research Area
Call for Paper: More Details
