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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Bone Cancer Pain, Therapeutic Opportunities, Causes and Consequences |
| Authors Name: | Rohit Pralhadrao Kale , Arun Balaji Sontakke , Sanket Ankushrao Jadhav , Abhishek Changdeo Suryawanshi |
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IJNRD_181255
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| Published Paper Id: | IJNRD2205017 |
| Published In: | Volume 7 Issue 5, May-2022 |
| DOI: | |
| Abstract: | The common type of cancers which are commonly found in the human beings include cancers of breast, prostate gland, lung which involves the metastasis to bones which lead to severe life altering pain. The progression of cancer drives the pain stimulus as well. After the metastasis of cells to bone, both cancer cells and their associated stromal cells generate the pain by releasing chemical messengers like endothelins, bradykinin, proteases, prostaglandins, and tyrosine kinase activators. These chemicals are released from the cancerous cells lead to introduce a sensitization and the activation of nerve fibers cause the bone pain. Along with bone pain these chemicals also can stimulate remarkable increase in the number activity of osteoclast and bone size which ultimately results into fracture of the bone that bears tumor. The growth in tumor part also may lead to neuropathic pain by causing damage to nerve fibre as well as inducing an active and highly pathological sprouting of both sensory and sympathetic nerve fibres that innervate the bone. The anatomical organization of the sympathetic nerve fibre and sensory nerve fibre are in combination with the cellular and neurochemical organization that occurs in CNS and appears to contribute in bone pain. |
| Keywords: | cancer, Bone growth, Pain, Sensations, Osteoclast, Experimental model |
| Cite Article: | "Bone Cancer Pain, Therapeutic Opportunities, Causes and Consequences", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 5, page no.159-164, May-2022, Available :http://www.ijnrd.org/papers/IJNRD2205017.pdf |
| Downloads: | 000118755 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2205017 Registration ID: 181255 Published In: Volume 7 Issue 5, May-2022 DOI (Digital Object Identifier): Page No: 159-164 Country: BEED, MAHARASHTRA, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2205017 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2205017 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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