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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | To explore the grape seed oil potentially in the management of Ageing |
| Authors Name: | Shradha Jaganath Sangle , Nishigandha Nandkishor Dhokale , Ankita Tukaram Jagtap , Kanchan Rajendra Kapse |
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| Author Reg. ID: |
IJNRD_181046
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| Published Paper Id: | IJNRD2204086 |
| Published In: | Volume 7 Issue 4, April-2022 |
| DOI: | |
| Abstract: | The passage of time (intrinsic ageing) and cumulative exposure to external effects (extrinsic ageing) such as ultraviolet radiation (UVR), which encourage wrinkle formation and tissue flexibility, can both cause skin to age. While both ageing processes cause phenotypic alterations in cutaneous cells, structural and compositional remodeling of ordinarily long-lived dermal extracellular matrix proteins causes the major functional signs of ageing. Before focusing on the processes, functional consequences, and treatment of elastic fiber remodeling in ageing skin, this article briefly discusses the impact of ageing on dermal collagens and proteoglycans. The differential degradation of elastic fibre proteins characterises the early stages of photoageing, and while the activity of extracellular matrix proteases is elevated in photoexposed skin, the substrate specificity of these enzymes is poor. However, we recently discovered that isolated fibrillin microfibrils are vulnerable to direct UV-B destruction at physiologically achievable concentrations, and that elastic fibre proteins are substantially concentrated in UV-absorbing amino acid residues as a group. Elastic fibre remodelling events can have a negative impact on: tissue mechanical properties, Immune cell recruitment and activation, matrix metalloproteinase production, and cytokine signalling (via disrupting TGF sequestration in fibrillin microfibrils). Finally, newly proposed topical therapies appear to be capable of regenerating elements of the elastic fibre system in ageing skin, while systemic treatments may be able to avoid pathological tissue remodelling processes that occur as a result of elastic fibre degradation. |
| Keywords: | To explore the grape seed oil potentially in the management of Ageing |
| Cite Article: | "To explore the grape seed oil potentially in the management of Ageing", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 4, page no.708-719, April-2022, Available :http://www.ijnrd.org/papers/IJNRD2204086.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2204086 Registration ID: 181046 Published In: Volume 7 Issue 4, April-2022 DOI (Digital Object Identifier): Page No: 708-719 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2204086 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2204086 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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