Paper Title
To explore the grape seed oil potentially in the management of Ageing
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To explore the grape seed oil potentially in the management of Ageing
Abstract
The passage of time (intrinsic ageing) and cumulative exposure to external effects (extrinsic ageing) such as ultraviolet radiation (UVR), which encourage wrinkle formation and tissue flexibility, can both cause skin to age. While both ageing processes cause phenotypic alterations in cutaneous cells, structural and compositional remodeling of ordinarily long-lived dermal extracellular matrix proteins causes the major functional signs of ageing. Before focusing on the processes, functional consequences, and treatment of elastic fiber remodeling in ageing skin, this article briefly discusses the impact of ageing on dermal collagens and proteoglycans. The differential degradation of elastic fibre proteins characterises the early stages of photoageing, and while the activity of extracellular matrix proteases is elevated in photoexposed skin, the substrate specificity of these enzymes is poor. However, we recently discovered that isolated fibrillin microfibrils are vulnerable to direct UV-B destruction at physiologically achievable concentrations, and that elastic fibre proteins are substantially concentrated in UV-absorbing amino acid residues as a group. Elastic fibre remodelling events can have a negative impact on: tissue mechanical properties, Immune cell recruitment and activation, matrix metalloproteinase production, and cytokine signalling (via disrupting TGF sequestration in fibrillin microfibrils). Finally, newly proposed topical therapies appear to be capable of regenerating elements of the elastic fibre system in ageing skin, while systemic treatments may be able to avoid pathological tissue remodelling processes that occur as a result of elastic fibre degradation.
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Shradha Jaganath Sangle, Nishigandha Nandkishor Dhokale, Ankita Tukaram Jagtap, & Kanchan Rajendra Kapse (April-2022). To explore the grape seed oil potentially in the management of Ageing. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(4), 708-719. https://ijnrd.org/papers/IJNRD2204086.pdf
Issue
Volume 7 Issue 4, April-2022
Pages : 708-719
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Paper Reg. ID: IJNRD_181046
Published Paper Id: IJNRD2204086
Downloads: 000122255
Research Area: Engineering
Author Type: Foreign Author
Country: -, -, -
Published Paper PDF: https://ijnrd.org/papers/IJNRD2204086.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2204086
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