Development and Validation of RP-HPLC method for determination of fosinopril sodium and Hydrochlorothiazide in Bulk and in tablet

Development and Validation of RP-HPLC method for determination of fosinopril sodium and Hydrochlorothiazide in Bulk and in tablet

Registration ID: IJNRD_180646

Published ID: IJNRD2203036

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Miss. Sayali Milind Patil , Mr. Anup R. Jawale , Mr. Sachin S. Rane , Dr. Rajesh Y. Chaudhari , Dr. Vijay R. Patil

Fosinopril Sodium, Hydrochlororthiazide, Validation, RP-HPLC, Simultaneous Estimation.

This assay method was Development and Validation of RP-HPLC Method for Determination of Fosinopril Sodium and Hydrochlororthiazide in Bulk and in tablets. They were both drugs separated by using RP-HPLC on a RP- Agilent C18 (250 mm ×4.6 mm I.D.) with particle size 5 µm was selected. On the basis of literature survey the mobile phase was acetonitrile and phosphate buffer was selected at 0.7 ml/min. The UV detector was operated the overlain spectra 233 nm was selected for the estimation of both drugs. Linearity, accuracy, precision, Ruggedness and System suitability test was found to be acceptable concentration ranges 12.5 – 62.5μg/ml for Hydrochlororthiazide and 10-50μg/ml for Fosinopril Sodium with a R20.999 and 0.999 values respectively, in this mixture of drugs.

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"Development and Validation of RP-HPLC method for determination of fosinopril sodium and Hydrochlorothiazide in Bulk and in tablet", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 3, page no.304-311, March-2022, Available :https://ijnrd.org/papers/IJNRD2203036.pdf

Volume 7 Issue 3, March-2022

Pages : 304-311

Paper Reg. ID: IJNRD_180646

Published Paper Id: IJNRD2203036

Downloads: 000121136

Research Area: Pharmacy

Country: Jalgaon, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2203036.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2203036

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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