Paper Title
Development and Validation of RP-HPLC method for determination of fosinopril sodium and Hydrochlorothiazide in Bulk and in tablet
Article Identifiers
Authors
Miss. Sayali Milind Patil , Mr. Anup R. Jawale , Mr. Sachin S. Rane , Dr. Rajesh Y. Chaudhari , Dr. Vijay R. Patil
Keywords
Fosinopril Sodium, Hydrochlororthiazide, Validation, RP-HPLC, Simultaneous Estimation.
Abstract
This assay method was Development and Validation of RP-HPLC Method for Determination of Fosinopril Sodium and Hydrochlororthiazide in Bulk and in tablets. They were both drugs separated by using RP-HPLC on a RP- Agilent C18 (250 mm ×4.6 mm I.D.) with particle size 5 µm was selected. On the basis of literature survey the mobile phase was acetonitrile and phosphate buffer was selected at 0.7 ml/min. The UV detector was operated the overlain spectra 233 nm was selected for the estimation of both drugs. Linearity, accuracy, precision, Ruggedness and System suitability test was found to be acceptable concentration ranges 12.5 – 62.5μg/ml for Hydrochlororthiazide and 10-50μg/ml for Fosinopril Sodium with a R20.999 and 0.999 values respectively, in this mixture of drugs.
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How To Cite (APA)
Miss. Sayali Milind Patil, Mr. Anup R. Jawale, Mr. Sachin S. Rane, Dr. Rajesh Y. Chaudhari, & Dr. Vijay R. Patil (March-2022). Development and Validation of RP-HPLC method for determination of fosinopril sodium and Hydrochlorothiazide in Bulk and in tablet. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(3), 304-311. https://ijnrd.org/papers/IJNRD2203036.pdf
Issue
Volume 7 Issue 3, March-2022
Pages : 304-311
Other Publication Details
Paper Reg. ID: IJNRD_180646
Published Paper Id: IJNRD2203036
Downloads: 000121999
Research Area: Pharmacy
Country: Jalgaon, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2203036.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2203036
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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