Paper Title
Development and validation of Q-Absorbance Ratio UV spectrophotometric Method for the simultaneous estimation of metformin and empagliflozin in bulk and pharmaceutical dosage form
Article Identifiers
Authors
Anup Jawale , Mr. Sachin S. Rane , Dr. Rajesh Y. Chaudhari , Dr. Vijay R. Patil , Dr. Lokesh G. Barde
Keywords
Empagliflozin, Metformin HCL, Absorption Ratio Method, ICH, Validation etc.
Abstract
A simple, robust, precise, UV spectroscopic method has been developed for the simultaneous estimation of Metformin HCL and Empagliflozin in bulk and tablet dosage forms. In this paper the estimation of those drugs was carried out by absorbance ratio method. This method is based on measurement of absorption at 235nm and 258nm i.e., λ max of Metformin and Isoabsorptive point of both Metformin HCL and Empagliflozin respectively. The linearity observed for Metformin HCL is in the range of 10-50μg/ml and for Empagliflozin is in the range of 3-11μg/ml. The accuracy of methods was assessed by recovery studies and was found to be within the range of 99.5%-100.5% for both Metformin HCL and Empagliflozin. The developed methods were validated with respect to linearity, accuracy (recovery), and precision. The method can be employed for estimation of pharmaceutical formulations with no interference from any other excipients and diluents. The results were validated as per ICH guidelines.
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How To Cite (APA)
Anup Jawale, Mr. Sachin S. Rane, Dr. Rajesh Y. Chaudhari, Dr. Vijay R. Patil, & Dr. Lokesh G. Barde (March-2022). Development and validation of Q-Absorbance Ratio UV spectrophotometric Method for the simultaneous estimation of metformin and empagliflozin in bulk and pharmaceutical dosage form. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(3), 284-295. https://ijnrd.org/papers/IJNRD2203034.pdf
Issue
Volume 7 Issue 3, March-2022
Pages : 284-295
Other Publication Details
Paper Reg. ID: IJNRD_180639
Published Paper Id: IJNRD2203034
Downloads: 000121977
Research Area: Pharmacy
Country: Jalgaon, MAHARASTRA, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2203034.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2203034
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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