Development and validation of Q-Absorbance Ratio UV spectrophotometric Method for the simultaneous estimation of metformin and empagliflozin in bulk and pharmaceutical dosage form

Development and validation of Q-Absorbance Ratio UV spectrophotometric Method for the simultaneous estimation of metformin and empagliflozin in bulk and pharmaceutical dosage form

Registration ID: IJNRD_180639

Published ID: IJNRD2203034

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Anup Jawale , Mr. Sachin S. Rane , Dr. Rajesh Y. Chaudhari , Dr. Vijay R. Patil , Dr. Lokesh G. Barde

Empagliflozin, Metformin HCL, Absorption Ratio Method, ICH, Validation etc.

A simple, robust, precise, UV spectroscopic method has been developed for the simultaneous estimation of Metformin HCL and Empagliflozin in bulk and tablet dosage forms. In this paper the estimation of those drugs was carried out by absorbance ratio method. This method is based on measurement of absorption at 235nm and 258nm i.e., λ max of Metformin and Isoabsorptive point of both Metformin HCL and Empagliflozin respectively. The linearity observed for Metformin HCL is in the range of 10-50μg/ml and for Empagliflozin is in the range of 3-11μg/ml. The accuracy of methods was assessed by recovery studies and was found to be within the range of 99.5%-100.5% for both Metformin HCL and Empagliflozin. The developed methods were validated with respect to linearity, accuracy (recovery), and precision. The method can be employed for estimation of pharmaceutical formulations with no interference from any other excipients and diluents. The results were validated as per ICH guidelines.

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"Development and validation of Q-Absorbance Ratio UV spectrophotometric Method for the simultaneous estimation of metformin and empagliflozin in bulk and pharmaceutical dosage form", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 3, page no.284-295, March-2022, Available :https://ijnrd.org/papers/IJNRD2203034.pdf

Volume 7 Issue 3, March-2022

Pages : 284-295

Paper Reg. ID: IJNRD_180639

Published Paper Id: IJNRD2203034

Downloads: 000121197

Research Area: Pharmacy

Country: Jalgaon, MAHARASTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2203034.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2203034

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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