Paper Title
Role of neuroglial cells in Neuroinflammations
Article Identifiers
: Keywords
Microglia; Astrocyte; Glial activation; Neuroinflammation; CNS; Interaction
Abstract
Glial cells throughout the nervous system are closely associated with synapses. Accompanying these anatomical couplings are intriguing functional interactions, including the capacity of certain glial cells are to respond and modulate neurotransmission. Glial cells can also help establish, maintain, and reconstitute synapses. Neuropathic pain refers to a variety of chronic pain conditions with differing underlying pathophysiologic mechanisms and origins. A common underlying mechanism of neuropathic pain is the presence of inflammation at the site of the damaged or affected nerve(s). This inflammatory response initiates a cascade of events resulting in the concentration and activation of innate immune cells at the site of tissue injury. The release of immunoreactive substances such as cytokines, neurotrophic factors, and chemokines initiate local actions and can result in a more generalized immune response. The resultant neuroinflammatory environment can cause activation of glial cells located in the spinal cord and the brain, which appear to play a prominent role in nociception. Glial cells, also known as neuroglia, are nonconducting cells that modulate neurotransmission at the synaptic level. Glial cells can be subdivided into two primary categories: microglia and macroglia, which include astrocytes and oligodendrocytes. Astrocytes and microglia are known to play a role in the development, spread, and potentiation of neuropathic pain. Microglia propagate the neuroinflammation by recruiting other microglia and eventually activating nearby astrocytes, which prolongs the inflammatory state and leads to a chronic neuropathic pain condition. Our review focuses on the role of glia and the immune system in the development and maintenance of neuropathic pain.
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How To Cite (APA)
SK. Abdul Saleem, D.Vijaya Lakshmi, SK.Nujahath, G.Baby, & J.N. Suresh Kumar (March-2022). Role of neuroglial cells in Neuroinflammations. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(3), 120-136. https://ijnrd.org/papers/IJNRD2203013.pdf
Issue
Volume 7 Issue 3, March-2022
Pages : 120-136
Other Publication Details
Paper Reg. ID: IJNRD_180573
Published Paper Id: IJNRD2203013
Downloads: 000122253
Research Area: Pharmacy
Author Type: Indian Author
Country: Guntur, Andhra Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2203013.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2203013
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