A Review on Therapeutic Applications of GSK-3 beta Inhibitors

Registration ID: IJNRD_180575

Published ID: IJNRD2203010

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Anu Jayamol Mathew , Aiswarya Suresh , Anu Yousef , Dr. Deepa Jose

Glycogen Synthase Kinase 3 Beta (GSK 3 Beta), Indazole Derivatives, GSK 3 Beta Inhibitors, Cancer, Alzheimer’s Disease, Diabetes

Abstract : Glycogen synthase kinase 3 beta (GSK-3 beta), which is a serine/threonine kinase was initially identified because of its key role in the regulation of glycogen synthesis. But it is now well-established that GSK-3 performs critical functions in many cellular processes, such as apoptosis, tumor growth, cell invasion, and metastasis. Many human disorders, including cancer, have been linked to abnormal GSK-3 activity, underlining its therapeutic promise as a cancer target. [29]. There is conflicting evidence on the effect of GSK-3 inhibition on cancer cell development due to multiple methods through which GSK-3 may influence carcinogenesis. It can act as a tumor promoter as well as a tumor suppressor in different types of cancers [14]. However, it is found that combination of GSK-3 beta inhibitors with chemotherapeutic agents can significantly reduce the resistance of various tumor cells towards the chemotherapy. In the last few years, many GSK-3 inhibitors have been developed, and some are currently being tested in clinical trials [16]. Indazoles are nitrogen-based heterocyclic chemicals that posses many types of biological activities and representatives of this class of pharmacological agents are widely used as antibacterial, anti-inflammatory, anti-HIV, Antiprotozoal and antimalarial agents. Recent studies are showing promising activity of indazole derivatives as anticancer agents.

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Anu Jayamol Mathew, Aiswarya Suresh, Anu Yousef, & Dr. Deepa Jose (March-2022). A Review on Therapeutic Applications of GSK-3 beta Inhibitors. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(3), 94-103. https://ijnrd.org/papers/IJNRD2203010.pdf

Volume 7 Issue 3, March-2022

Pages : 94-103

Paper Reg. ID: IJNRD_180575

Published Paper Id: IJNRD2203010

Downloads: 000121986

Research Area: Pharmacy

Country: Ernakulam, Kerala, India

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