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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | BRIEF STUDY AND THEIR PREFORMULATION PARAMETERS ON A DRUG: TENOFOVIR DISOPROXIL FUMARATE |
| Authors Name: | Pratima jayasawal , Dr N.G. Raghavendra Rao , Dr. Pranshu tangri , Jyoti saxena |
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IJNRD_180317
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| Published Paper Id: | IJNRD2006035 |
| Published In: | Volume 5 Issue 6, June-2020 |
| DOI: | |
| Abstract: | Tenofovir disoproxil fumarate (tenofovir DF) is a bioavailable prodrug of tenofovir, a potent nucleotide analogue reverse-transcriptase inhibitor with activity against human immunodeficiency virus (HIV) and hepatitis B virus. It is administered as a single 300-mg tablet once daily. It was approved for the treatment of HIV infection on the basis of data from clinical trials demonstrating activity in treatment-experienced patients, and it was subsequently shown to be effective when used as a component of initial therapy. Tenofovir DF is active against some nucleoside-resistant strains of HIV. However, cross-resistance is associated with multiple thymidine analogue mutations that include 41L or 210W. The signature mutation is the K65R mutation, which causes variable loss in susceptibility to tenofovir DF, didanosine, and abacavir. Tenofovir DF has been well tolerated in clinical trials with durations of follow-up up to 96 weeks. It is associated with more-favorable lipid profiles than stavudine and has not been associated with the mitochondrial toxicity attributed to other nucleoside analogues. |
| Keywords: | Tenofovir , Hiv , nrti |
| Cite Article: | "BRIEF STUDY AND THEIR PREFORMULATION PARAMETERS ON A DRUG: TENOFOVIR DISOPROXIL FUMARATE", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.5, Issue 6, page no.314-325, June-2020, Available :http://www.ijnrd.org/papers/IJNRD2006035.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2006035 Registration ID: 180317 Published In: Volume 5 Issue 6, June-2020 DOI (Digital Object Identifier): Page No: 314-325 Country: Dehradun, Uttarakhand, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2006035 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2006035 |
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