BRIEF STUDY AND THEIR PREFORMULATION PARAMETERS ON A DRUG: TENOFOVIR DISOPROXIL FUMARATE

BRIEF STUDY AND THEIR PREFORMULATION PARAMETERS ON A DRUG: TENOFOVIR DISOPROXIL FUMARATE

Registration ID: IJNRD_180317

Published ID: IJNRD2006035

DOI: Click Here to Get

Pratima jayasawal , Dr N.G. Raghavendra Rao , Dr. Pranshu tangri , Jyoti saxena

Tenofovir , Hiv , nrti

Tenofovir disoproxil fumarate (tenofovir DF) is a bioavailable prodrug of tenofovir, a potent nucleotide analogue reverse-transcriptase inhibitor with activity against human immunodeficiency virus (HIV) and hepatitis B virus. It is administered as a single 300-mg tablet once daily. It was approved for the treatment of HIV infection on the basis of data from clinical trials demonstrating activity in treatment-experienced patients, and it was subsequently shown to be effective when used as a component of initial therapy. Tenofovir DF is active against some nucleoside-resistant strains of HIV. However, cross-resistance is associated with multiple thymidine analogue mutations that include 41L or 210W. The signature mutation is the K65R mutation, which causes variable loss in susceptibility to tenofovir DF, didanosine, and abacavir. Tenofovir DF has been well tolerated in clinical trials with durations of follow-up up to 96 weeks. It is associated with more-favorable lipid profiles than stavudine and has not been associated with the mitochondrial toxicity attributed to other nucleoside analogues.

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"BRIEF STUDY AND THEIR PREFORMULATION PARAMETERS ON A DRUG: TENOFOVIR DISOPROXIL FUMARATE", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.5, Issue 6, page no.314-325, June-2020, Available :https://ijnrd.org/papers/IJNRD2006035.pdf

Volume 5 Issue 6, June-2020

Pages : 314-325

Paper Reg. ID: IJNRD_180317

Published Paper Id: IJNRD2006035

Downloads: 000121177

Research Area: Pharmacy

Country: Dehradun, Uttarakhand, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2006035.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2006035

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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