Paper Title
Design, Synthesis and screening of some novel pyrimidines as Antihistaminic (H1 antagonist).
Article Identifiers
Authors
Vishal Chudasama , Kiran Suthar , Megha Patel , Bharat Rajpurohit
Keywords
Pyrimidine, H1 receptor, Antiallergic, Anticholinergic, Sedative, Pharmacophore
Abstract
Novel pyrimidines were designed to meet the triangular pharmacophore requirement of histamine H1 receptor. Substituted Pyrimidine ring were prepared via two component synthesis method by the condensation of S, N Acetal with Symmetrical S-methyldiarylisothiourea. The structures of the synthesized compounds were confirmed using spectroscopic techniques. These compounds were also screened for anti-histaminic activity. The recorded pA2 showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug cetirizine. Compounds were also evaluated for their sedative potential as well as their anticholinergic activities as these two are known to be the common adverse effects of histamine H1-receptor antagonists.
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How To Cite (APA)
Vishal Chudasama, Kiran Suthar, Megha Patel, & Bharat Rajpurohit (May-2019). Design, Synthesis and screening of some novel pyrimidines as Antihistaminic (H1 antagonist).. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 4(5), 107-114. https://ijnrd.org/papers/IJNRD1905016.pdf
Issue
Volume 4 Issue 5, May-2019
Pages : 107-114
Other Publication Details
Paper Reg. ID: IJNRD_225026
Published Paper Id: IJNRD1905016
Downloads: 000121984
Research Area: Pharmacy
Country: Khambhat, Gujarat, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD1905016.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD1905016
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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