Histological Effect of Curcumin on Aortic Changes 'Induced By Obesity' in the Male Albino Rats (Light and Electron Microscopic Study)

Histological Effect of Curcumin on Aortic Changes 'Induced By Obesity' in the Male Albino Rats (Light and Electron Microscopic Study)

Registration ID: IJNRD_183803

Published ID: IJNRD1903005

DOI: Click Here to Get

Ahmad Mohammad Abdel-Aleem Desoky

Obesity, Triton, Curcumin, Aorta, Cardiovascular, Albino rats

Background: Obesity can incidence ischemic heart disease and stroke (the leading causes of mortality worldwide). Curcumin can protect against atherosclerosis and platelet aggregation. The aim of this work was to study the light and electron microscopic changes induced by obesity in aorta of albino rats and the possible role of curcumin in their correction. Material and methods: Eighty male albino rats were divided into four groups: Control group: fed normal laboratory diet for one month. Obese group: received one intraperitoneal injection of Triton (250 mg/kg) to induce obesity and fed normal laboratory diet for one month. Recovery group: similar to obese group but left for another month. Treated group: similar to obese group but treated with oral curcumin (50 mg/kg/day) for another month. Finally, body weight and serum lipid profile were measured. Aortic samples were taken for LM and EM study. LM slides were photographed and analyzed while ultra-thin sections were examined by TEM. For statistical analysis: means, standard errors and P-values were calculated (for body weight, serum lipid profile, atherosclerotic indices, thickness of aortic tunica intima and number of vascular smooth muscle cells "VSMCs" in aortic tunica media). Results: Body weight, serum lipid profile and atherosclerotic indices showed significant increase in obese group then significant improvement in treated group. LM study revealed significant increase in both intimal thickness and VSMCs number of obese group then insignificant improvement in recovery group and significant improvement in treated group. EM study of obese group revealed thickened intima, endothelial "hook like projection", wide sub-endothelial space, ruptured internal elastic lamina "IEL" and increased interstitial fibers. Recovery group revealed slight improvement in intimal thickness, interstitial fibers but ruptured IEL still present. Treated group revealed marked improvement in the form of smooth endothelial surface, narrow sub-endothelial space and continuous IEL, however, few interstitial fibers still present.

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"Histological Effect of Curcumin on Aortic Changes 'Induced By Obesity' in the Male Albino Rats (Light and Electron Microscopic Study)", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.4, Issue 3, page no.23-34, March-2019, Available :https://ijnrd.org/papers/IJNRD1903005.pdf

Volume 4 Issue 3, March-2019

Pages : 23-34

Paper Reg. ID: IJNRD_183803

Published Paper Id: IJNRD1903005

Downloads: 000121141

Research Area: Medical Science

Country: Cairo, Cairo, Egypt

Published Paper PDF: https://ijnrd.org/papers/IJNRD1903005.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD1903005

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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