VON WILLEBRAND DISEASE: A BRIEF OVERVIEW

VON WILLEBRAND DISEASE: A BRIEF OVERVIEW

Registration ID: IJNRD_170038

Published ID: IJNRD1705018

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Kiran B. Kotade , Neha S. Golesar , Sachin B.Somwanshi , Ramdas T. Dolas

Von Willebrand Disease (VWD), von Willebrand Factor (vWF), Bleeding.

Von Willebrand Disease is a common inherited bleeding disorder characterized by excessive bleeding caused by a deficiency or abnormality of Von Willebrand Factor (VWF). VWF is a multimeric adhesive protein produced mainly by the endothelial cells. Characteristic bleeding symptoms include epitaxis, easy bruishing, oral cavity bleeding, and menorrhagia, bleeding after dental extraction, surgery and childbirth. In severe cases bleeding into joints and soft tissues may occur. There are three subtypes: type 1 and 3 represents quantitative variants and type 2 is group of four qualitative variants(type2A, 2B, 2M, 2N).The diagnosis of von willebrand disease requires specialized assays of von willebrand factor and/or molecular genetic testing of von willebrand factor. Severe bleeding episodes can be prevented or controlled with intravenous infusions of virally inactivated plasma derived clotting factor concentrates containing both von willebrand factor and factor VIII. Depending on the type of von willebrand disease, mild bleeding episodes usually respond to intravenous or subcutaneous treatment with desmopressin a vasopressin analogue. Other treatments that can reduce symptoms include fibrinolytic inhibitors and hormones for menorrhagia.

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"VON WILLEBRAND DISEASE: A BRIEF OVERVIEW", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.2, Issue 5, page no.81-86, May-2017, Available :https://ijnrd.org/papers/IJNRD1705018.pdf

Volume 2 Issue 5, May-2017

Pages : 81-86

Paper Reg. ID: IJNRD_170038

Published Paper Id: IJNRD1705018

Downloads: 000121176

Research Area: Pharmacy

Country: Sinnar,Nashik, Maharashtra , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD1705018.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD1705018

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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