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Authors Name: Kiran B. Kotade , Neha S. Golesar , Sachin B.Somwanshi , Ramdas T. Dolas
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Published Paper Id: IJNRD1705018
Published In: Volume 2 Issue 5, May-2017
Abstract: Von Willebrand Disease is a common inherited bleeding disorder characterized by excessive bleeding caused by a deficiency or abnormality of Von Willebrand Factor (VWF). VWF is a multimeric adhesive protein produced mainly by the endothelial cells. Characteristic bleeding symptoms include epitaxis, easy bruishing, oral cavity bleeding, and menorrhagia, bleeding after dental extraction, surgery and childbirth. In severe cases bleeding into joints and soft tissues may occur. There are three subtypes: type 1 and 3 represents quantitative variants and type 2 is group of four qualitative variants(type2A, 2B, 2M, 2N).The diagnosis of von willebrand disease requires specialized assays of von willebrand factor and/or molecular genetic testing of von willebrand factor. Severe bleeding episodes can be prevented or controlled with intravenous infusions of virally inactivated plasma derived clotting factor concentrates containing both von willebrand factor and factor VIII. Depending on the type of von willebrand disease, mild bleeding episodes usually respond to intravenous or subcutaneous treatment with desmopressin a vasopressin analogue. Other treatments that can reduce symptoms include fibrinolytic inhibitors and hormones for menorrhagia.
Keywords: Von Willebrand Disease (VWD), von Willebrand Factor (vWF), Bleeding.
Cite Article: "VON WILLEBRAND DISEASE: A BRIEF OVERVIEW", International Journal of Novel Research and Development (, ISSN:2456-4184, Vol.2, Issue 5, page no.81-86, May-2017, Available :
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