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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD)
An International Open Access Journal |   ISSN: 2456-4184 |  IMPACT FACTOR: 5.57

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Issue: December 2020

Volume 5 | Issue 12

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Impact Factor : 5.57

Issue per Year : 12

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Paper Title: Development and validation of RP-HPLC method for simultaneous estimation of Atorvastatin and Irbesartan for combined dosage form
Authors Name: Vijaya M Gaikwad , Vivekanand A Kashid , Kiran B Kotade
Author Reg. ID:
IJNRD_180338
Published Paper Id: IJNRD2011039
Published In: Volume 5 Issue 11, November-2020
Abstract: ABSTRACT A specific, precise and accurate RP-HPLC method has been developed for simultaneous estimation of irbesartan and atorvastatin in synthetic mixture. The use of a 250 × 4.6 mm, 5 µm particle size, C18 column with 50: 10: 40 %, v/v/v acetonitrile: methanol: 0.1 % formic acid (pH adjusted to 3.5 with triethylamine) as isocratic mobile phase at flow rate of 1 ml/min enabled separation of drugs. UV detection was performed at 271 nm. The method was validated as per ICH Q2(R1) guidelines. The retention time for irbesartan and atorvastatin were found to be 4.01 ± 0.03 and 7.03 ± 0.03 min respectively. The linearity of method was satisfactory over the range 300-1500 ng (correlation coefficient 0.9993) and 20-100 ng (correlation coefficient 0.9996) for irbesartan and atorvastatin respectively. The limits of detection for irbesartan and atorvastatin were 10.94 and 1.33 ng respectively. The limits of quantitation for irbesartan and atorvastatin were 33.14 and 4.03 ng respectively. Recovery of irbesartan and atorvastatin ranged from 99.84-99.98 % and 99.90-100.67 % respectively. The method was successfully applied to synthetic mixture for quantitative analysis of irbesartan and atorvastatin. Keyword- Irbesartan, Atorvastatin, RP-HPLC, analysis
Keywords: Irbesartan, Atorvastatin, RP-HPLC, UV, Validation
Cite Article: "Development and validation of RP-HPLC method for simultaneous estimation of Atorvastatin and Irbesartan for combined dosage form", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.5, Issue 11, page no.347-391, November-2020, Available :http://www.ijnrd.org/papers/IJNRD2011039.pdf
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