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Paper Title: Effects on the dynamics of insulin analogues in diabetes using two time delays
Authors Name: Dr Nilam
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Published Paper Id: IJNRD1712001
Published In: Volume 2 Issue 12, December-2017
Abstract: Management of type 1 diabetes and severe type 2 diabetes rely on exogenous insulin or insulin analogues to control raised blood glucose concentration. Insulin lispro and insulin aspart are rapid acting insulin analogue which have a shortened delay of onset and are easily absorbed in the bloodstream. Insulin analogue exists in hexameric, dimeric and monomeric states and hexameric form dissociates into dimeric and monomeric form which can penetrate the capillary membrane and can be absorbed into plasma. For different insulin analogues the transformation of hexameric state into dimeric and monomeric state takes different time which will be considered as first time delay in the present study. More the time it will take in this transformation, utilization of insulin in the body will be delayed which will be termed as second time delay. Therefore, an attempt has been made to find the ranges of these two time delays for the concoction of better rapid acting insulin analogues for better management of glucose and insulin concentration in diabetics through DDE model. The pro le of plasma insulin concentration level obtained from simulation of the model are in good agreement with previously observed results for the quantified range of both time delays.
Keywords: insulin analogus, diabetes, mathematical modeling, time delay
Cite Article: "Effects on the dynamics of insulin analogues in diabetes using two time delays", International Journal of Novel Research and Development (, ISSN:2456-4184, Vol.2, Issue 12, page no.1-7, December-2017, Available :
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