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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Effects on the dynamics of insulin analogues in diabetes using two time delays |
| Authors Name: | Dr Nilam |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_170162
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| Published Paper Id: | IJNRD1712001 |
| Published In: | Volume 2 Issue 12, December-2017 |
| DOI: | |
| Abstract: | Management of type 1 diabetes and severe type 2 diabetes rely on exogenous insulin or insulin analogues to control raised blood glucose concentration. Insulin lispro and insulin aspart are rapid acting insulin analogue which have a shortened delay of onset and are easily absorbed in the bloodstream. Insulin analogue exists in hexameric, dimeric and monomeric states and hexameric form dissociates into dimeric and monomeric form which can penetrate the capillary membrane and can be absorbed into plasma. For different insulin analogues the transformation of hexameric state into dimeric and monomeric state takes different time which will be considered as first time delay in the present study. More the time it will take in this transformation, utilization of insulin in the body will be delayed which will be termed as second time delay. Therefore, an attempt has been made to find the ranges of these two time delays for the concoction of better rapid acting insulin analogues for better management of glucose and insulin concentration in diabetics through DDE model. The pro le of plasma insulin concentration level obtained from simulation of the model are in good agreement with previously observed results for the quantified range of both time delays. |
| Keywords: | insulin analogus, diabetes, mathematical modeling, time delay |
| Cite Article: | "Effects on the dynamics of insulin analogues in diabetes using two time delays", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.2, Issue 12, page no.1-7, December-2017, Available :http://www.ijnrd.org/papers/IJNRD1712001.pdf |
| Downloads: | 000118754 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD1712001 Registration ID: 170162 Published In: Volume 2 Issue 12, December-2017 DOI (Digital Object Identifier): Page No: 1-7 Country: Delhi, Delhi, India Research Area: Applied Mathematics Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD1712001 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD1712001 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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